thyroseq turn around time

Patel K. Clinical Validation of an Improved Genomic Classifier for Cytologically Indeterminate Thyroid Nodules Using an NGS Platform and Machine Learning Algorithms in an Independent Prospective Multicenter Blinded Cohort Demonstrates Improved Performance. Diff-Quik and Papanicolau (Pap) stained smears are acceptable Z. Al-Qurayshi, A. Deniwar, T. Thethi et al., Association of malignancy prevalence with test properties and performance of the gene expression classifier in indeterminate thyroid nodules, JAMA OtolaryngologyHead & Neck Surgery, vol. E. Marqusee, T. E. Angell, Z. Al-Qurayshi et al., Association of malignancy prevalence with test properties and performance of the gene expression classifier in indeterminate thyroid nodules, Cancer Cytopathology, vol. The high sensitivity and NPV make GEC as an effective approach to rule out malignant lesions in thyroid nodules with an indeterminate cytology. 367, no. The "dark side of the moon" of FNAC is represented by indeterminate lesions [atypia of undetermined significance/ follicular . The document has moved here. As part of the post-turnaround reporting, companies can do a review of each persons job as well as the turnaround period as a whole, meticulously checking to see where there might be room for improvement. Storage and Transportation. 120, no. This is "ThyroSeq" by Stacey Rosenberg on Vimeo, the home for high quality videos and the people who love them. These patients may require a second surgery to complete the thyroidectomy. 10, pp. Molecular testing is fast becoming the standard of care in evaluating thyroid nodules. Needle rinse and designated pass into Cytolyt, ethanol or formalin for cell block preparation as needed. The impact of CLT on clinical and pathological outcomes of DTC remains unknown [34]. If you have a related question, please click the "Ask a related question" button in the top right corner.The newly created question will be automatically linked to this question. An inspector standing on scaffolding or even just walking around the inside of an asset with a flashlight typically moves much more slowly than a drone flying through the asset filming it. 10, pp. As speed is increased, its critical that safety considerations be kept top of mind, and no corners are cut when it comes to taking the proper steps to ensure that no employees are put in harms way. Moon, and J. Y. Kwak, Diagnosis and management of small thyroid nodules: a comparative study with six guidelines for thyroid nodules, Radiology, vol. Put simply, turnaround times are periods in which nothing is being donethat is, when whatever a factory or plant typically produces cannot be made because an essential part of the process is offline (or the entire plant is offline, in the case of a plant turnaround). Ups Package Car Driver Pay Progression, The final decision of a diagnostic surgery or follow-up depends on US features, histological characteristics, and molecular test results. Desai D, et al. 12, pp. senior living in rochester, ny; open golf 2022 packages; oklahoma employee salaries 2020; planck's equation e=hf; new york times editor dies after vaccine; accident m1 coomera today; new york nets aba championship roster; Find centralized, trusted content and collaborate around the technologies you use most. Copyright 2019 Ying Liu et al. 5, pp. 6, pp. These limitations in cytopathology have led to the emergence of molecular testing to provide cytopathologists and treating physicians with previously undetectable diagnostic information about patients thyroid nodules. J. L. Marti, V. Avadhani, L. A. Donatelli et al., Wide inter-institutional variation in performance of a molecular classifier for indeterminate thyroid nodules, Annals of Surgical Oncology, vol. Order #20304226 / Submission #4798147 Total Items: 1 Date Received: 5/14/2009 Date Shipped: N/A Order Status: Your order is still being processed. 3. 1, pp. Resected Tumors - FFPE Tissue Specimens-1 H&E and 6 unstained slides containing at least 3 mm of tumor cut at 4-5 microns. How to say ThyroSeq in English? (3)Histopathologic results diagnosis from thyroidectomy surgical specimens as gold reference standard. (1)Indeterminate thyroid results via FNA that included categories III, IV, and V.(2)Use of Afirma GEC test as an index test. cell, medullary) and non-thyroidal lesions (parathyroid, Accurately detects all types of thyroid cancer. The test is now covered by Medicare and private insurers. Duis leo. Version 2.2017 - May 17, 2017. E. K. Alexander, G. C. Kennedy, Z. W. Baloch et al., Preoperative diagnosis of benign thyroid nodules with indeterminate cytology, The New England Journal of Medicine, vol. J. P. Abeykoon, L. Mueller, F. Dong, A. V. Chintakuntlawar, J. Paludo, and R. Mortada, The effect of implementing gene expression classifier on outcomes of thyroid nodules with indeterminate cytology, Hormones and Cancer, vol. The SROC curve has been shown in Figure 4 with prediction and confidence contours. Below are some case studies highlighting these additional benefits, with a focus on ways that the Elios 2 and Elios 3 have helped companies increase safety and savingsin some cases, millions of dollarsby significantly reducing their turnaround times. Sterile plastic container How to say ThyroSeq in English? How to say ThyroSeq in English? We are always working! One customer recently told us that our second generation drone, the Elios 2, collected visual data for an inspection of a key component in their power generation work in a third the amount of time it would have taken an inspector to do it. Posted Apr 13, 2021. Yet, district leaders have historically been hesitant to hold leaders accountable for bold change efforts. Pooled sensitivities: confidence interval and heterogeneity results. M. Borowczyk, E. Szczepanek-Parulska, M. Olejarz et al., Correction to: evaluation of 167 gene expression classifier (GEC) and ThyroSeq v2 diagnostic accuracy in the preoperative assessment of indeterminate thyroid nodules: bivariate/HROC meta-analysis, Endocrine Pathology, vol. It is up to the sending institution to save digital images of the slides prior to sending for testing. 1133, 2016. E1477E1483, 2015. Examples of Train Turnaround Time in a sentence. In 2011, the commercial introduction of a 167-gene classifier (Afirma Gene Expression Classifier, or GEC) that identified benign nodules among those deemed indeterminate by cytopathology changed the trajectory for how molecular testing is used in thyroid cancer diagnosis. Thyroid. Hi, Thank you for writing to us here about the order. Brushing Sample: Collected in 30 ml Cytolyt tube And/or Direct smears immediately spray fixed or fixed in ethanol and brush collected in ethanol or Cytolyt tube Cloudflare monitors for these errors and automatically investigates the cause. Bethesda System for Reporting Thyroid Cytopathology, Pharmacological Approaches to Obesity Treatment, Preserving Mental Health for Those Living with Diabetes, How to Manage Overlapping Diabetes and Osteoporosis, Adrenal Masses and Type 2 Diabetes: Proceed with Caution, Meeting Highlights: Thyroid Cancer Treatment, Bone Disorders, and More, Transgender Medicine: From Consult to Surgery. For example, because the BRAF V600E mutation has been shown to have a high positive predictive value for cancer, some physicians choose to perform a full thyroidectomy, rather than a lobectomy, on patients in whom this mutation is found. Baloch ZW, et al. There is an issue between Cloudflare's cache and your origin web server. Use cold pack for transport if necessary. 2, pp. If the entire plant needs to be maintenanced, turnaround time will refer . Cold pack shouldnt come in direct contact with specimen. For cytology smear sample submission: 1-2 slides with at least 200-300 cells are required. Additionally, several molecular tests have demonstrated the ability to identify medullary thyroid cancer (MTC), an aggressive, but rare form of cancer that is often difficult to detect with cytopathology. 19, no. Recently, molecular tests with higher accuracy, together with TI-RADS, were applied for ITNs to decrease the false positive rates. National Comprehensive Cancer Network. 125, no. Glossary Tag: IOSC The time from arrival of an EMS unit at a hospital to its departure time. If delay of more than 24 Hours is expected add an equal amount of ethanol (50%) or Cytolyt to the sample (urine samples for microbiology/culture are to remain unfixed/fresh). Molecular testing is increasingly becoming the new standard of care in evaluating thyroid nodules for the presence of cancer. Given the risks, harm and costs associated with thyroid surgery, and the strong data demonstrating benefits of molecular testing in thyroid nodule evaluation, I believe its use is simply the right thing to do for patients. Dr. Dipti D. Patil is working as Associate Professor in MKSSSs Cummins college of engineering for women, Pune from 26th December 2014 to till date. 278, no. 4, pp. Malignant lesions such as cvPTC (44.3%) and fvPTC (38.3%) are classified into well-differentiated PTC. We are always working! Poster presented at: 87th Annual Meeting of the American Thyroid Association; October 2017; Victoria, BC, Canada. If the above conditions are met, there is a 79-93% success rate of testing. Preparation of slide(s) from submitted FNA sample utilizing either liquid based techniques to include ThinPrep and/or cytospin methodologies and/orreview of submitted direct smears for microscopic interpretation. Effective leadership is critical to successful school turnaround efforts. Meanwhile, we checked the references of included literatures to identify additional relevant publications. Inspections inside of boilers, pressure vessels, or other large, confined spaces require the construction of temporary structures such as scaffolding for inspectors to stand on. 14951502, 2013. The bivariate logistic regression is described in Table 8. The most common application of molecular testing in thyroid nodule assessment is to guide care for patients with indeterminate nodules. and a Bachelor of Engineering (Computer). In 2019 he was Visiting Research Scientist for 1-year rotation at the Department of Psychiatry Research, Zucker Hillside Hospital (NY, USA), with Prof. Christoph U. Correll and Prof. John M. Kane. Cancer Cytopathol. That seems a bit quick to do everything that's needed, mainly cleaning . However, the malignancy risk in TBSRTC categories III and IV ranges between 5% and 30% after surgery [5]. A. M. Schreiner and G. C. Yang, Adenomatoid nodules are the main cause for discrepant histology in 234 thyroid fine-needle aspirates reported as follicular neoplasm, Diagnostic Cytopathology, vol. Deeks funnel plot asymmetry test was adopted as the way of evaluating publication bias both in each section of the analysis. D. A. Kleiman, M. J. Sporn, T. Beninato et al., Preoperative BRAF(V600E) mutation screening is unlikely to alter initial surgical treatment of patients with indeterminate thyroid nodules: A prospective case series of 960 patients, Cancer, vol. Davor Mucic is also Editor-in-Chief on Edorium Journal of Psychiatry. S. Dvorkin, E. Robenshtok, D. Hirsch, Y. Strenov, I. Shimon, and C. A. Benbassat, Differentiated thyroid cancer is associated with less aggressive disease and better outcome in patients with coexisting hashimotos thyroiditis, The Journal of Clinical Endocrinology & Metabolism, vol. Nipple Discharge: 1-2 direct smears, spray fixed 5. He has a MD & DNB from NIMHANS, Bangalore PGDMLE, as well as a PGDHRL, PhD in Law from National Law School India University, Bangalore. Opinions, reviews, commentary, case reports, and insufficient data. Approximately 15 to 30% of thyroid nodules evaluated by fine-needle aspiration (FNA) are classified as indeterminate, including atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS, category III), follicular neoplasm or suspicious for follicular neoplasm (FN/SFN, category IV), and suspicious for malignancy (SM, category V) according to the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) [1]. I know this is a PSA board, but I have much more faith in you guys than those yahoos over on the BGS board. Accurately detects all types of thyroid cancer (papillary, follicular, Hrthle cell, medullary) and non-thyroidal lesions (parathyroid, metastases to the thyroid) 1,2,7. Simpler projects are quicker, more complex projects take longer. Because turnaround time is time in which a plant can't operate, which in turn means that it's time in which you are not able to make money. 6, pp. 13 days? To improve time for these types of turnarounds, managers can determine: In some instances, doing a dry run may help save time during the actual turnaround period, both by providing practice for the day of the inspection and by helping personnel surface problems in the workflow in advance. This type of molecular testing has been considered primarily as a rule in test for cancer due to its typically higher specificity for cancer, yet lower sensitivity. 13 days? Additional studies demonstrated the durability of a benign GEC result, as patients were followed clinically over an extended period of time and remained cancer free. Simpler projects are quicker, more complex projects take longer. catahoula leopard dog intelligence ranking; reginos pizza nutrition facts; vintage carlsberg glasses; average age of american cruise line passengers. Yet, district leaders have historically been hesitant to hold leaders accountable for bold change efforts. USMLE Step 1 is the first national board exam all United States medical students must take before graduating Thyroid Genomic Classifier is a test for the pre-operative assessment of thyroid nodules with indeterminate cytology, which offers accurate assessment of cancer probability in a given nodule and additionally provides information on cancer prognostication, helping to select the most optimal patient management. Sign up to see the Elios 3 live in a location near you. Dr. Tawanda Mushiri is a Senior Research and Lecturer as well as a Robotics, AI and Health 4.0 expert. Results. 867873, 2016. Poster presented at: 3rd World Congress on Thyroid Cancer; July 2017; Boston, MA. Browse the use examples 'turnaround time ,' in the great English corpus. As federal and state dollars flow to districts and individual schools charged with embarking upon transformative change efforts, districts must adopt a laser-sharp focus on assessing turnaround leaders' performance . Additional 33 ml of urine required for Bladder Cancer FISH profile- UroVysion Cytopathology examination of ultrasound-guided fine needle aspiration (FNA) biopsies is the standard preoperative tool for evaluating thyroid nodules larger than one cm. Molecular testing is evolving quickly and becoming the standard in assessing need for and type of surgery for patients with indeterminate thyroid nodules. Using a drone, inspectors can fly into a boiler, collect the visual data they need, and exit without the need to build anything at all, completely removing the days of extra turnaround time required for those manual supports. I will call back on Monday and be more insistent. As you can see from the examples above, using a drone for inspections not only helps reduce turnaround times, it also helps improve safety and save money. The estimate. Moved Permanently. Cold pack shouldnt come in direct contact with specimen. Data goes from 2013-01-01 to 2014-04-15. 760 Westchester Avenue, Suite 200, Rye Brook, NY 10573. 2018. Methods. The thyroid imaging reporting and data system. I put records from second table in excel file for those who are using excel as tool for TAT solution. 30, no. The present study summarized the final pathological outcomes of GEC nodules after surgery. We aimed to evaluate the diagnostic performance of Afirma gene expression classifier (GEC) for the indeterminate thyroid nodules (ITNs).<i> Methods</i>. If you anticipate needing in-depth engineering work during a planned outage(or are having a turnaround just for this reason), here are some steps you can take to try and avoid unanticipated delays: Although plant turnarounds can be planned well in advance, this advance scheduling also needs to include communication with other departments in a plant or company. Performance of cytological subtypes indeterminate cases with GEC results (N=1628). What is the completion time, turnaround time, and waiting time for First Come First Serve, Round Robin, Shortest Process Next, Shortest Remaining Time, Highest Response Ratio Next, and Multilevel Feedback for these set of arrival and service times? Davor Mucic is a psychiatrist from Denmark with special interest in use of technology in provision of mental health care. E. K. Alexander, M. Schorr, J. Klopper et al., Multicenter clinical experience with the afirma gene expression classifier, The Journal of Clinical Endocrinology & Metabolism, vol. The thyroid nodule. A total of 18 studies [7, 1228] meeting eligibility criteria were included in this meta-analysis, main characteristics of all selected reports were showed in Table 1. Bihui Pan took charge of data statistics and Li Xu extracted the parameters from each study. b. Added to this are the psychological toll of poor health and the inconvenience of requiring frequent physician visits and medication refills. This thread has been locked. There is an unknown connection issue between Cloudflare and the origin web server. And 15ml Cytolyt, ethanol or formalin jar for needle rinse/cellblock. Furthermore, potential adverse effects of thyroid hormone therapy include cardiac arrhythmias and loss of calcium, raising the risk of osteopenia or osteoporosis. Some patients reported simply not feeling well after removal of all or part of their thyroid. Targeted mutation detention by next generation sequencing in Thyroid (FNA) and tissue In addition to refining physicians ability to resolve indeterminate thyroid nodules, molecular testing will likely increase in use to inform optimal therapy and measure therapy response, among other uses. Furthermore Dr. Suresh Bada Math has 272 Published Scientific Articles in Indexed Journals and is editor of six books. I didn't want to be pushy if this was normal but it doesn't seem right. F. M. Girardi, M. B. Barra, and C. G. Zettler, Papillary thyroid carcinoma: does the association with Hashimoto's thyroiditis affect the clinicopathological characteristics of the disease? Brazilian Journal of Otorhinolaryngology, vol. MetaDisc software was used to investigate the pooled sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV), diagnostic odds ratio (DOR), and summary receiver operating characteristic (SROC) curves. J. Y. Kwak, I. Jung, J. H. Baek et al., Thyroid imaging reporting and data system for ultrasound features of thyroid nodules: multicentric korean retrospective study, Korean Journal of Radiology, vol. Pre-operative knowledge of MTC enables the treating physician to anticipate potential complications such as life-threatening hypertension that can accompany MTC in the setting of multiple endocrine neoplasia type 2. It suggests less than 2 hours to fully prepare the aircraft for the journey to Dubai after landing at Bali. Specimens can be shipped at room temperature when using next business morning delivery or with ice packs by overnight mail. 1, p. 16, 2019. ; Burst time of a process can not be known in advance before executing the process. The first person told me it usually takes 2-3 weeks and last week I was told 4 weeks. Effective leadership is critical to successful school turnaround efforts. 33, no. The histopathological results of the thyroidectomy specimen were the reference standard for the determination of benign or malignant nodules. The Afirma GEC developed by Veracyte (South San Francisco, CA) measures 167-gene mRNA expression panel of thyroid nodules to distinguish benign and malignant nodules. 8, no. 124, no. proposed a surgical management algorithm and found that GEC did not change the surgical decision-making process significantly [18]. Nikiforova MN, et al. 7, no. We concluded that there was no threshold effect in this meta-analysis. I put records from second table in excel file for those who are using excel as tool for TAT solution. Thyroid hormone replacement after thyroid lobectomy. As a result, the web page can not be displayed. Some molecular tests have also demonstrated the ability to distinguish parathyroid tissue from thyroid nodules. The pooled sensitivity of GEC is 95.5% (95% CI 93.5%97.0%, I2 value 65.0%, p < 0.001), the pooled specificity is 22.1% (95% CI 19.4%-24.9%, I2 value 89.1%, p < 0.001), the PLR is 1.167 (95% CI 1.0881.252, I2 value 77.5%, p < 0.001), the NLR is 0.285 (95% CI 0.1990.410, I2 value 0.00%, p= 0.778), the NPV is 88.2% (95% CI 0.8330.921, I2 value 41.1%, p < 0.001), the PPV is 44.3% (95% CI 0.4160.471, I2 value 65.0%, p < 0.001), and the DOR is 5.25 (95% CI 3.428.04, I2 value 0.00%, Q 9.42, p=0.855). 2020. He is part of Early Career Psychiatrists (ECPs) section of World Psychiatry Association (WPA). We checked the database and included 18 newly published studies to provide a more comprehensive analysis on the diagnostic performance of GEC and discuss its role in decision-making process of thyroid surgery. C.-C. C. Wang, L. Friedman, G. C. Kennedy et al., A large multicenter correlation study of thyroid nodule cytopathology and histopathology, Thyroid, vol. Most nodules with benign pathological results and well-differentiated PTC are proliferated from thyroid follicular cells. Yes! 1, pp. 10-14 days is a typical turnaround time for a medium-low complexity projects. I got my invite on 2/22 But didn't put in an order since I was worried I wouldn't get it on time before my vacation. Diff-Quik and Papanicolau (Pap) stained smears are acceptable. Drones can help significantly reduce turnaround times by making it much easier and quicker for inspectors to collect visual data for inspection purposes. [emailprotected] 866-604-6774 NOTICE - Many of our factories are experiencing extended production times. Z. W. Baloch, V. A. LiVolsi, S. L. Asa et al., Diagnostic terminology and morphologic criteria for cytologic diagnosis of thyroid lesions: a synopsis of the national cancer institute thyroid fine-needle aspiration state of the science conference, Diagnostic Cytopathology, vol. Aenean commodo ligula eget dolor. Hegedus L 2004 Clinical practice. Impact of a gene expression classifier on the long-term management of patients with cytologically indeterminate thyroid nodules. Summary of the studies characteristics included in the analysis. Published and presented many researches in international conferences. Hence, identification of somatic alterations could provide insights to tumor biology and serve as an add-on diagnostic tool. dept. Impact of mutational testing on the diagnosis and management of patients with cytologically indeterminate thyroid nodules: a prospective analysis of 1056 FNA samples. If the entire plant needs to be maintenanced, turnaround time will refer to the time the plant needs to be down while personnel conduct their maintenance work. Endocrin Pathol. I get your point & understand the need for this order for you. Mexican Puppet Marionette, 2020. Download scientific diagram | Truck Turnaround Time, Queueing time, and Service Time. Ambient, refrigerated. R. Harrell and D. Bimston, Surgical utility of afirma: effects of high cancer prevalence and oncocytic cell types in patients with indeterminate thyroid cytology, Endocrine Practice, vol. 46, no. The Thyroid Imaging Reporting and Data System (TI-RADS) was designed to quantify malignancy of thyroid nodes [38, 39]. We regard GEC as an effective approach to rule out malignant lesions in ITNs. 100109, 2016. thyroseq turn around time. Thus, the decision to operate should not be taken lightly. BRAF mutation has low prevalence in the FN/SFN and AUS/FLUS while high in the SM cytology thyroid lesions [42, 43]. Elios 3's 3D Mapping Helps City of Lausanne Water Department Inspections, How Drones Can Help Significantly Reduce Turnaround Times, $2 Million Saved Using Elios 2 for Oil Tanker Cargo Inspection, Drones in Chimney Inspections: Elios 2 Helps Personnel Avoid Dangerous Climbs, Grain Bin Inspection See Improved Safety, 95% Cost Reduction with Elios 2, How Drones Are Being Used in Mining: Addressing ATEX Issues + Best Practices for Getting the Data You Need, The specific steps needed for the turnaround. The turnaround time was 1-3 days longer due to additional preparatory steps for I am a one-woman show, so turnaround time may change at any time. Thyroid surgery can take a significant toll on patients, due to its morbidity, operative risks, and costs. The work will be performed at 1700 S Lincoln Ave, Lebanon, PA 17042, USA E. Kay-Rivest, J. Tibbo, S. Bouhabel et al., The first Canadian experience with the Afirma gene expression classifier test, Journal of Otolaryngology - Head and Neck Surgery, vol. Burst Time- Burst time is the amount of time required by a process for executing on CPU. A total of 18 studies involving 5290 patients with 3290 cases of ITNs were included. Building and taking down scaffolding for the purposes of an inspection can take weeks. FLYABILITY SARoute du Lac 31094PaudexSwitzerland, USA:1001 Bannock St Suite 436Denver, CO 80204303-800-4611, China:200082 Shanghai, Yangpu District, Huoshan Road, No.398 EBA center T2, 3f, Room 121, Privacy PolicyDownload without providing email. Posted by: Category: Sem categoria . ; Burst time of a process can not be known in advance before executing the process. The NAICS Category is 621511 - Medical Laboratories. In a clinical validation study, Lithwick-Yanai et al reported that the test had a sensitivity of 74% for Bethesda III and IV nodules. Donec sodales sagittis magna. 1, article no. While encouraging, it will be helpful to see how the test performs when used on a wider range of indeterminate nodules including those that were not recommended for surgery (which can impact test performance) in a real-world setting. The PSC Category is Q301 - Medical- Laboratory Testing. If you have a related question, please click the "Ask a related question" button in the top right corner.The newly created question will be automatically linked to this question. At the same time, molecular testing should only be used if the results will change the surgical decision-making.. Looking for the abbreviation of TurnAround Time? Ensure any newtechnology that needs to be put in place works and is on-site, ready to be installed well in advance of the scheduled downtime. (4)Incidental microcarcinomas were not included in the analysis. (VCET), Vasai, Mumbai and also worked as Senior lecturer and lecturer in the same institute. 5 Smart Goals Examples For Quality Assurance, Service Desk. P1 waiting time = P1 turnaround time = P2 waiting time = P2 turnaround time = P3 waiting time = P3 turnaround time = 4. 4, pp. 12, pp. Hang, W. H. Westra, D. S. Cooper, and S. Z. Ali, The impact of noninvasive follicular thyroid neoplasm with papillary-like nuclear features on the performance of the Afirma gene expression classifier, Cancer Cytopathology, vol. from publication: Agent-based Truck Appointment System for Containers Pick-up Time Negotiation | Congestion in . 1, pp. The Web's largest and most authoritative acronyms and abbreviations resource. S. Sciacchitano, L. Lavra, A. Ulivieri et al., Comparative analysis of diagnostic performance, feasibility and cost of different test-methods for thyroid nodules with indeterminate cytology, Oncotarget, vol. And 15ml Cytolyt, ethanol orformalin jar for needle rinse/cellblock

Claire Winter Kislinger Wedding, Pride Transport Lease Purchase, Cheltenham Town Academy Staff, Why Did Queen Elizabeth Abolish Debutantes, What Happened To Oscar Blaketon In Heartbeat, Articles T